Search Result

Search Results for " il-1 α "

Targets

Compounds

Natural Products

1777

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T22698	TLR3-IN-1	CU CPT 4a	TLR
	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...		TLR
T3147	Pyrrolidinedithiocarbamate ammonium	PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate	NF-κB
	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.		NF-κB
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T2367	SKF-86002	SKF86002	p38 MAPK , TNF
	SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).		p38 MAPK , TNF
T11742	K-7174		IL Receptor , TNF
	K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.		IL Receptor , TNF
T9645	CU-115	N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR
	CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.		TLR
T76727	Teprotumumab	R 1507,HZN 001	TSH Receptor , IGF-1R
	Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te...		TSH Receptor , IGF-1R
T13063	T6167923		MyD88
	T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6...		MyD88
T24816	SP-100030	SP100030,SP 100030	NF-κB
	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ...		NF-κB
T7672	MD2-TLR4-IN-1		TLR
	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.		TLR
T77582	Anti-inflammatory agent 51		NF-κB
	Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative col...		NF-κB
T38294	4-Deoxypyridoxine hydrochloride		S1P Receptor
	4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib...		S1P Receptor
T79025	TNF-α-IN-10
	TNF-α-IN-10 (compound 8a) acts as an inhibitor of IL-6 and TNF-α, demonstrating anti-inflammatory activity [1].
T11742L	K-7174 dihydrochloride		mTOR
	K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.		mTOR
T35450	α-GalCer analog 8	α-GalCer analog 8,α-Galactosylceramide analog 8
	α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-load...
T63088	NOD2 antagonist 1
	NOD2 antagonist 1 (compound 32) is an effective and selective NOD2 antagonist (IC50: 5.23μM). NOD2 antagonist 1 in THP-1 cells repress Muramyl DiDP (MDP) -induced IL-8 secretion. NOD2 antagonist 1 in PBMCs cells inhibits...
T72102	Glucocorticoid receptor modulator 1
	Glucocorticoid receptor modulator 1 is a potent, orally active, non-steroidal selective glucocorticoid receptor modulator, exhibiting IC50 values of 9 nM and 130 nM against NF-κB and AP-1, respectively. It effectively re...
T76602	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a corticotropin-releasing factor (CRF) antagonist known to counteract the inhibitory effects of IL-1a on Luteinizing hormone (LH) production [1].
T77179	Remtolumab
	Remtolumab (ABT-122), a dual-variable domain immunoglobulin, neutralizes tumor necrosis factor α (TNFα) and IL-17A, demonstrating dual inhibition of both. This compound is utilized in rheumatoid arthritis (RA) research [...
T38008	KBC-007
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3...
T79256	DPP-4-IN-8
	DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM. It inhibits the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells and...
T77169	Simlukafusp alfa
	Simlukafusp alfa (FAP-IL2v) is an immunocytokine that consists of an antibody targeting fibroblast activation protein α (FAPα) linked to a variant of IL-2, which specifically interacts with IL-2Rβγ. The compound is of th...
T83457	12R-LOX-IN-1
	12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses the hyperproliferative condition and the ability to form colonies in Imiquimod-induced psoriatic keratinocytes, as well as r...
T83048	Anti-inflammatory agent 64		ROS Kinase
	Anti-inflammatory agent 64 (compound 4b) exhibits antioxidant and anti-inflammatory activities, effectively inhibiting the secretion of IL-6 and TNF-α while also reducing paw edema [1] in both in vitro and in vivo studie...		ROS Kinase
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κ...
T77036	Inolimomab
	Inolimomab, an anti-interleukin-2 receptor (IL-2R) α chain monoclonal antibody, has demonstrated potential to enhance survival rates in preliminary studies addressing acute graft-versus-host disease (aGVHD) [1] [2].
T38339	R-8507
	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, resp...
T74908	ODN 2336
	ODN 2336, an A-Class CpG oligodeoxynucleotide (ODN), serves as a potent TLR9 agonist. It effectively induces IFN-α production and up-regulates IP-10 and IL-18 mRNA expression, leveraging its role as a vaccine adjuvant [1...
T82233	HCAR2 agonist 1
	HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokin...
T80697	β5i-IN-1		Proteasome
	β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM. It modulates immune responses by promoting the release of TNF-α and IL-6 and affecting NF-κB transcriptional activity. This c...		Proteasome
T77080	Manfidokimab
	Manfidokimab (AK120), an IgG4 monoclonal antibody targeting the interleukin 4 receptor alpha (IL-4Rα), demonstrates therapeutic efficacy as detailed in reference [1].
T78829	JNK2-IN-1		JNK
	JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and IL-6 secretion via inhibition of the NF-κB/MAPK pathway. It e...		JNK
T79585	Anti-inflammatory agent 50		NF-κB
	Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and TNF-α. It mitigates acute lung injury by modulating these me...		NF-κB
T79385	PDE1-IN-5
	PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demon...
T83670	F1 TFA	Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide
	F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectivel...
T61302	Anti-inflammatory agent 17
	Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo stu...
T36011	P38 MAP Kinase Inhibitor IV	p38 MAPK Inhibitor IV
	p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α an...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...
T78508	Delmitide acetate	RDP-58 acetate	IFNAR
	Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties. This compound suppresses the production of TNF-α, IFN-γ, and interleukin (IL)-12, while enhancing the ...		IFNAR
T79304	Semapimod	CPSI-2364,CNI-1493 free base
	Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide ...
T78953	SIMR3030		SARS-CoV
	SIMR3030, a potent inhibitor of SARS-CoV-2 PLpro, possesses an IC50 of 0.0399 µg/mL and demonstrates antiviral activity by diminishing the expression of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030...		SARS-CoV
T74911	ODN 24987
	ODN 24987, a Guanine-modified inhibitory oligonucleotides (ODN) designed to target TLR9, efficiently suppresses the release of IL-6 and IFN-α, showcasing its potential utility in research on immune disorders. The sequenc...
T61709	AMS-17
	AMS-17 is a potent NLRP3 inhibitor, which effectively suppresses microglia activation both in vitro and in vivo. Additionally, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-α, IL-1β, and...
T79619	Anti-inflammatory agent 54
	Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-α, IL-6, an...
T74910	ODN 24888
	ODN 24888, a guanine-modified inhibitory oligonucleotide (INH-ODN), effectively inhibits TLR7/TLR9-mediated signaling, reducing IFN-α levels and NF-κB activation, and suppressing IL-6 release. This compound plays a role ...
T75094	STING agonist-26
	STING agonist-23 (CF508), a non-nucleotide small-molecule STING agonist, activates STING, thereby enhancing the phosphorylation of STING, TBK1, and IRF3. This activation elevates the production of IFN-β, IL-6, CXCL-10, T...
T74907	ODN 21595
	ODN 21595, a guanine-modified inhibitor targeting TLR7 and TLR9, effectively inhibits the release of IFN-α and IL-6 without exhibiting cytotoxicity. It also reduces the expression of CD86 and HLA-DR, showcasing potential...
T75092	STING agonist-24
	STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-...
T61071	AX-024
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. Wi...
T37590	ML 3403
	p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively). Laufer et al (2003) Novel substituted pyr...

Compounds

Pyrrolidinedithiocarbamate ammonium

T3147

Synonym: PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

SKF-86002

T2367

Synonym: SKF86002

Target: p38 MAPK, TNF

K-7174

T11742

Synonym:

Target: IL Receptor, TNF

CU-115

T9645

Synonym: N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide

Target: TLR

Teprotumumab

T76727

Synonym: R 1507,HZN 001

Target: TSH Receptor, IGF-1R

Synonym: SP100030,SP 100030

Anti-inflammatory agent 51

T77582

Synonym:

Target: NF-κB

4-Deoxypyridoxine hydrochloride

K-7174 dihydrochloride

Synonym: α-GalCer analog 8,α-Galactosylceramide analog 8

Glucocorticoid receptor modulator 1

T72102

Synonym:

Target:

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)

Anti-inflammatory agent 64

T83048

Synonym:

Target: ROS Kinase

6(5H)-Phenanthridinone

Anti-inflammatory agent 50

Synonym: Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide

Target:

Anti-inflammatory agent 17

T61302

Synonym:

Target:

p38 MAP Kinase Inhibitor IV

T36011

Synonym: p38 MAPK Inhibitor IV

Synonym: RDP-58 acetate

Target: IFNAR

Semapimod

T79304

Synonym: CPSI-2364,CNI-1493 free base

Anti-inflammatory agent 54

Cat No.	Product Name	Synonyms	Targets
TC0036	Compound Lup-20(29)-en-3-yl acetate		IL Receptor , VEGFR , Others , TNF , COX
	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.		IL Receptor , VEGFR , Others , TNF , COX
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin
T3887	Rosarin		Others
	Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .		Others
TN1154	Nepetin	6-Methoxyluteolin	Calcium Channel , Histamine Receptor
	Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.		Calcium Channel , Histamine Receptor
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis
T5S1981	Alpha-Cyperone	(+)-α-Cyperone,α-Cyperone	Others , Endogenous Metabolite
	1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced...		Others , Endogenous Metabolite
T6S1579	Monotropein	Monotropeine	Others
	1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf...		Others
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T4S2063	Tetrahydrocoptisine	STYLOPINE	ERK , p38 MAPK , NF-κB
	1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo...		ERK , p38 MAPK , NF-κB
T2S2264	Linalool	Linalol,(±)-Linalool,Phantol	Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
	1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T79970	Taxamairin B
	Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces the production of NO and ROS in LPS-induced RAW264.7 cells. Furthermore, ...
TN5238	Viscidulin II		IL Receptor , TNF
	Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of ...		IL Receptor , TNF
T75694	Lacto-N-neotetraose
	Lacto-N-neotetraose (LNnT), an endogenous metabolite, inhibits TNF-α-induced IL-8 secretion in immature epithelial cells, exhibits anti-inflammatory activity, and enhances wound closure [1] [2] [4].
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin ...
TN5593	Euphohelioscopin A
	Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it ex...
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the pa...

Natural Products

Compound Lup-20(29)-en-3-yl acetate

TC0036

Synonym:

Target: IL Receptor, VEGFR, Others, TNF, COX

Mulberroside A

T6S1597

Synonym:

Target: TNF, Tyrosinase, Interleukin

Synonym: 6-Methoxyluteolin

Target: Calcium Channel, Histamine Receptor

Neobavaisoflavone

T6S0139

Synonym:

Target: Apoptosis, DNA/RNA Synthesis

alpha-Cyperone

T5S1981

Synonym: (+)-α-Cyperone,α-Cyperone

Target: Others, Endogenous Metabolite

Monotropein

T6S1579

Synonym: Monotropeine

Target: IL Receptor, TNF, TLR, JAK, STAT

Saikosaponin A

T2768

Synonym:

Target: NF-κB, Antibacterial, Liver X Receptor

Tetrahydrocoptisine

T4S2063

Synonym: STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Linalool

T2S2264

Synonym: Linalol,(±)-Linalool,Phantol

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Negletein

T2S0843

Synonym: 7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Target: IL Receptor, TNF

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01738	IL-1 alpha/IL-1A Protein, Mouse, Recombinant	Mouse	E. coli
	IL-1 alpha/IL-1A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is P01582.
TMPY-00854	IL-1 alpha/IL-1A Protein, Human, Recombinant	Human	HEK293 Cells
	IL-1 alpha/IL-1A Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18 kDa and the accession number is P01583.
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPK-00474	IL-22RA1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o...
TMPJ-00162	IL-1 alpha/IL-1A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-1 alpha/IL-1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 54 KDa and the accession number is P01583.
TMPY-01047	IL-1R1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-1R1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63 kDa and the accession number is P14778.
TMPY-01258	IL-13RA1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1.
TMPY-00856	TCCR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TCCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q6UWB1.
TMPY-01170	IL-13RA1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-13RA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is O09030.
TMPY-02879	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)	Human	E. coli
	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158) is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q9UHA7.
TMPY-01250	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is Q64385.
TMPK-00920	IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and b...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPK-00289	IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low af...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPY-05836	IL-1 alpha/IL-1A Protein, Rat, Recombinant	Rat	E. coli
	IL-1 alpha/IL-1A Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.80 kDa and the accession number is P16598.
TMPJ-00161	IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated	Human	E. coli
	IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated is expressed in E. coli expression system with C-Avi tag. The predicted molecular weight is 19 KDa and the accession number is P01583.
TMPK-00317	IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00512	IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)	Cynomolgus	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00316	IL-18R alpha Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00356	IL-27RA/TCCR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the ...
TMPJ-00291	IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to...
TMPJ-01424	IL-10R alpha/IL-10RA Protein, Macaca mulatta, Recombinant (His)	Macaca Mulatta	HEK293 Cells
	Interleukin-10 Receptor alpha (IL-10 R alpha), also known as IL-10 R1, is transmembrane glycoprotein member of the class II cytokine receptor family. Interleukin-10 (IL10) is a key anti-inflammatory cytokine that is prod...
TMPY-01048	IL-1R1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-1R1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is P14778.
TMPY-03426	IL-1R1 Protein, Human, Recombinant	Human	HEK293 Cells
	IL-1R1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.8 kDa and the accession number is P14778.
TMPK-00334	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is Q13651.
TMPK-00537	IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.34 kDa and the accession number is A0A2K5WJ66.
TMPK-00335	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is Q13651.
TMPK-00272	IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,...
TMPK-00273	IL-13Ra1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,...
TMPJ-00119	IL-22RA2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin-22 Receptor Subunit α-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. I...
TMPY-06579	IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated	Human	HEK293 Cells
	IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 40.15 kDa and the accession number is NP_001551.1.
TMPY-05543	TCCR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TCCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is AAC40121.1.
TMPY-06590	IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc)	Human	HEK293 Cells
	IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.62 kDa and the accession number is NP_001551.1.
TMPY-06792	TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 56.37 kDa and the accession number is AAC40121.1.
TMPY-01074	IL-13RA1 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	IL-13RA1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 65 kDa and the accession number is P78552-1.
TMPY-05123	IL-13RA1 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	IL-13RA1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1.
TMPY-01956	IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant	Mouse	E. coli
	IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q9JLA2-1.
TMPY-00454	IL-28B Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-28B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8CGK6.
TMPY-05795	IL-13RA1 Protein, Mouse, Recombinant (mFc)	Mouse	HEK293 Cells
	IL-13RA1 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 62.41 kDa and the accession number is O09030.
TMPY-05432	IL-13RA1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IL-13RA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.8 kDa and the accession number is O09030.
TMPY-02818	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)	Human	E. coli
	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.2 kDa and the accession number is Q9UHA7.
TMPJ-00270	IL-13RA1 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	Interleukin-13 receptor subunit alpha-1(IL-13RA1), also known as NR4, belongs to the hemopoietin receptor family. Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. It interacts with TR...
TMPY-00076	IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P26952-1.
TMPY-00592	IL-3R alpha/CD123 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-3R alpha/CD123 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.9 kDa and the accession number is EDL20630.1.
TMPJ-00981	PTX3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory...
TMPJ-00051	IL-3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPY-02549	GBP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 ex...
TMPJ-00968	NAMPT Protein, Human, Recombinant (His)	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e...
TMPY-05353	CCL26 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3),...
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IL-1 alpha/IL-1A Protein, Mouse, Recombinant

TMPY-01738

Species: Mouse

Expression System: E. coli

IL-1 alpha/IL-1A Protein, Human, Recombinant

TMPY-00854

Species: Human

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

TMPY-06981

Species: Human

Expression System: E. coli

IL-22RA1 Protein, Cynomolgus, Recombinant (His)

TMPK-00474

Species: Cynomolgus

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Human, Recombinant (hFc)

TMPJ-00162

Species: Human

Expression System: HEK293 Cells

IL-1R1 Protein, Human, Recombinant (hFc)

TMPY-01047

Species: Human

Expression System: HEK293 Cells

IL-13RA1 Protein, Human, Recombinant (His)

TMPY-01258

Species: Human

Expression System: HEK293 Cells

TCCR Protein, Human, Recombinant (hFc)

TMPY-00856

Species: Human

Expression System: HEK293 Cells

IL-13RA1 Protein, Mouse, Recombinant (His)

TMPY-01170

Species: Mouse

Expression System: HEK293 Cells

IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)

TMPY-02879

Species: Human

Expression System: E. coli

IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)

TMPY-01250

Species: Mouse

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)

TMPK-00920

Species: Cynomolgus

Expression System: HEK293 Cells

IL-22RA1 Protein, Human, Recombinant (hFc)

TMPK-01105

Species: Human

Expression System: HEK293 Cells

IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)

TMPK-00289

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Mouse, Recombinant (hFc)

TMPK-01071

Species: Mouse

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Rat, Recombinant

TMPY-05836

Species: Rat

Expression System: E. coli

IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated

TMPJ-00161

Species: Human

Expression System: E. coli

IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00317

Species: Human

Expression System: HEK293 Cells

IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)

TMPK-00512

Species: Cynomolgus

Expression System: HEK293 Cells

IL-18R alpha Protein, Human, Recombinant (His & Avi)

TMPK-00316

Species: Human

Expression System: HEK293 Cells

IL-27RA/TCCR Protein, Human, Recombinant (His)

TMPK-00356

Species: Human

Expression System: HEK293 Cells

IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated

TMPJ-00291

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Macaca mulatta, Recombinant (His)

TMPJ-01424

Species: Macaca Mulatta

Expression System: HEK293 Cells

IL-1R1 Protein, Human, Recombinant (His)

TMPY-01048

Species: Human

Expression System: HEK293 Cells

IL-1R1 Protein, Human, Recombinant

TMPY-03426

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi)

TMPK-00334

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His)

TMPK-00537

Species: Cynomolgus

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00335

Species: Human

Expression System: HEK293 Cells

IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00272

Species: Human

Expression System: HEK293 Cells

IL-13Ra1 Protein, Human, Recombinant (hFc)

TMPK-00273

Species: Human

Expression System: HEK293 Cells

IL-22RA2 Protein, Human, Recombinant (hFc)

TMPJ-00119

Species: Human

Expression System: HEK293 Cells

IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated

TMPY-06579

Species: Human

Expression System: HEK293 Cells

TCCR Protein, Mouse, Recombinant (His)

TMPY-05543

Species: Mouse

Expression System: HEK293 Cells

IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc)

TMPY-06590

Species: Human

Expression System: HEK293 Cells

TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated

TMPY-06792

Species: Mouse

Expression System: HEK293 Cells

IL-13RA1 Protein, Human, Recombinant (His & hFc)

TMPY-01074

Species: Human

Expression System: HEK293 Cells

IL-13RA1 Protein, Human, Recombinant (His), Biotinylated

TMPY-05123

Species: Human

Expression System: HEK293 Cells

IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant

TMPY-01956

Species: Mouse

Expression System: E. coli

IL-28B Protein, Mouse, Recombinant (His)

TMPY-00454

Species: Mouse

Expression System: HEK293 Cells

IL-13RA1 Protein, Mouse, Recombinant (mFc)

TMPY-05795

Species: Mouse

Expression System: HEK293 Cells

IL-13RA1 Protein, Mouse, Recombinant (hFc)

TMPY-05432

Species: Mouse

Expression System: HEK293 Cells

IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)

TMPY-02818

Species: Human

Expression System: E. coli

IL-13RA1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

TMPJ-00270

Species: Mouse

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc)

TMPY-00076

Species: Mouse

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Mouse, Recombinant (His)

TMPY-00592

Species: Mouse

Expression System: HEK293 Cells

PTX3 Protein, Mouse, Recombinant (His)

TMPJ-00981

Species: Mouse

Expression System: HEK293 Cells

IL-3 Protein, Mouse, Recombinant (His)

TMPJ-00051

Species: Mouse

Expression System: HEK293 Cells

GBP1 Protein, Human, Recombinant (His)

TMPY-02549

Species: Human

Expression System: HEK293 Cells

NAMPT Protein, Human, Recombinant (His)

TMPJ-00968

Species: Human

Expression System: E. coli

CCL26 Protein, Human, Recombinant

TMPY-05353

Species: Human

Expression System: Baculovirus Insect Cells

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Cat No.	Product Name
L3800	NF-κB Signaling Compound Library		729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;

Libraries

NF-κB Signaling Compound Library

L3800

Compounds: 729